Most common 2021 Mercedes-Benz E450 problems
Share of the 7 complaints; one complaint can involve more than one system. "~" is the median mileage when the problem started.
Mercedes-Benz E450 complaints by model year
Best E450 years: 2025, 2024. Years to avoid: 2023. Compare all years →
2021 Mercedes-Benz E450 recalls (14)
Electrical system › Wiring
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The 48-volt ground cable connection located in the engine compartment may not be tightened properly and may result in the ground cable overheating.
Remedy: Dealers will inspect the 48-volt ground cable connection and repair it as necessary, free of charge. Owner notification letters were mailed March 22, 2024. Owners may contact MBUSA customer service at 1-800-367-6372.
Electrical system › 12V/24V/48V battery
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2022 CLS450 Coupe and AMG E53, 2019-2021 AMG CLS53 Coupe, and 2021-2022 E450 vehicles. The 12-Volt battery in the trunk may not be properly secured, which, in the event of a crash, can cause electrical connection failure, disabling various safety features including,…
Remedy: Dealers will secure the 12V battery, free of charge. Owner notification letters were mailed January 20, 2023. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022100009.
Communication › Auto crash notification
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2017-2022 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, AMG GT-Class, C-Class, E-Class, S-Class, SL-Class, GLC-Class, CLS-Class, GLB-Class, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details.
Remedy: The communication module software will be updated through an Over-the-Air (OTA) update or by a dealer, free of charge. Owner notification letters were mailed July 8, 2022.
Back over prevention › Display function
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2018-2021 CLA-Class, GLE/GLS-Class, A-Class, C-Class, E-Class, E-Class Coupe/Convertible, GLA/GLB-Class, GLC-Class, and CLS-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details.
Remedy: Dealers will update the rearview camera software, free of charge. Owner notification letters were mailed July 15, 2022. Owners may contact MBUSA customer service at 1-800-367-6372.
Steering › Steering wheel/handle bar
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel.
Remedy: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372.
Air bags › Sensor › Side impact
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 CLS450, AMG E53, AMG CLS53, E350, E450, AMG GT43, AMG GT53, 2020 S450, S560, G550, AMG GLC63, 2020-2021 GLC300, and AMG G63 vehicles. The side crash sensor connectors may come loose, which could delay the activation of air bags and seatbelts during a side impact crash.
Remedy: Dealers will inspect and replace as necessary, the side impact crash sensors, free of charge. Owner notification letters were mailed on September 3, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.
Show 8 more recalls
Seat belts › Rear/other › Retractor
Mercedes-Benz, LLC (MBUSA) is recalling certain 2021 G550, AMG G63, E350, E450, AMG CLS53, AMG E53, AMG GT43, AMG GT53, AMG GT63, 2021-2022 CLS450, and AMG E63 vehicles. The rear seat belt automatic locking retractors may deactivate early, which can prevent the child restraint system from securing properly.
Remedy: Dealers will inspect, and replace as necessary, the rear seat belt assemblies, free of charge. Owners notified of the voluntary recall campaign by an interim letter on August 13, 2021.
Seats › Mid/rear assembly › Head restraint
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C300 Cabriolet, C43 AMG Cabriolet, C63 AMG Cabriolet, C63 AMG S Cabriolet, E450 Cabriolet, and E53 AMG Cabriolet vehicles. The rear headrests may be incorrectly mounted to the seatbacks.
Remedy: Dealers will inspect the rear seatback guide bushings and replace them if necessary, free of charge. Owner notification letters were mailed July 16, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.
Electrical system › Software
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2021 CLA-Class, GLE/GLS-Class, A-Class, E-Class, E-Class Coupe and Convertible, GLA/GLB-Class, GLC-Class, CLS-Class, and AMG GT-Class 4-door Coupe vehicles. Please refer to MBUSA's recall report for specific vehicle model details.
Remedy: The multimedia system software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. Owner notification letters were mailed beginning June 28, 2021.
Back over prevention › Warnings › External/pedestrian alert
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, and AMG E63 vehicles. The parking control unit may fail to display the rearview camera image and cause the parking sensors to misidentify or fail to detect objects.
Remedy: All affected vehicles are still within MBUSA's control. MBUSA will replace the parking control unit, free of charge. The recall began April 8, 2021. Owner may contact MBUSA customer service at 1-800-367-6372.
Seats
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 C-Class, E-Class, E-Class Coupe and Convertible, GLC, CLS, AMG GT 4-door Coupe and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle model details.
Remedy: MBUSA will notify owners, and dealers will replace the seat position switches, free of charge. Owner letters were mailed May 21, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.
Seats › Front assembly › Power adjust
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021 E350, E450, E450 Wagon, E63S AMG, 2020 E63S AMG Wagon, and 2020-2021 E53 AMG vehicles. The passenger seat limiter may allow the seat to be positioned too close to the air bag.
Remedy: MBUSA will notify owners, and dealers will recalibrate the passenger seat limiter, free of charge. The recall began April 29, 2021. Owners may contact MBUSA customer service at 1-800-367-6372.
Communication › Auto crash notification
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2016 - 2021 CLA-Class, GLA-Class, GLE-Class, GLS-Class, SLC-Class, A-Class, GT-Class, C-Class, E-Class, S-Class, CLS-Class, SL-Class, B-Class, GLB-Class, GLC-Class, and G-Class vehicles. Please refer to the Part 573 report for specific vehicle model details.
Remedy: MBUSA will notify owners, and the communication module software will be updated by a dealer, or through an over-the-air (OTA) update, free of charge. The recall began March 12, 2021.
Seats
Mercedes-Benz USA, LLC. (MBUSA) is recalling certain 2021 E350 and E450, 2019-2021 AMG E53 and 2020-2021 AMG E63 vehicles. The front passenger seat may be missing the mechanical seat adjustment range limit stop, allowing the seat to move outside of the acceptable range in relation to the air bag.
Remedy: MBUSA will notify owners, and dealers will inspect for the mechanical seat adjustment range limitation for the front passenger seat and install it if necessary, free of charge. The recall began December 18, 2020.
What 2021 Mercedes-Benz E450 owners say
Electrical system
48Volt battery failed after three months and just 3,400 miles. I understand this is a recurring problem with Mercedes. Car had to be towed as the vehicle was totally inoperable due to battery malfunction. It took more than three weeks for Mercedes to provide a replacement battery. From what I have read, there is a strong likelihood that the battery will fail again.
I bought this car on 12/12/2021 and two weeks after that, the car had warning message on dashboard "coolant too hot, stop the vehicle" on the highway -nj tunpike. It started slowing down on its own to below 20mph, nearly killed me while I tried to pull it over. Then the dealer service said it had defective water pump. Then last week 4/13/21 - 4 month,about 2800 milege on it, it wouldn't start at all., jump start didn't even work. So I was stranded again in the middle of the night. It got towed and they said it had defective battery. So how many defective parts this car has. It will keep breaking down and threaten my life on the highway where I commute every day in the night time. They should take this car back and replace but the dealer refused because it had problems on different parts and fixed. …
2021 Mercedes-Benz E450 engines & fuel economy
| Engine | Transmission | Drive | MPG city / hwy / combined |
|---|---|---|---|
| 3.0L 6-cyl turbo hybrid | 9-speed automatic | RWD | 23 / 31 / 26 |
EPA ratings. Class: Subcompact car.
Frequently asked questions
Is the 2021 Mercedes-Benz E450 a good car?
Based on 7 owner complaints filed with NHTSA, the 2021 E450 rates average: about as many complaints as a typical year of the E450 at the same age. Complaint counts don't account for sales volume or individual maintenance, so have any used car inspected before buying.
What is the most common problem with the 2021 Mercedes-Benz E450?
The electrical system — 3 complaints, 43% of all complaints for this model year, most often about 12v/24v/48v battery. Next are the engine & cooling (2) and wheels & tires (1).
How many recalls does the 2021 Mercedes-Benz E450 have?
There are 14 recalls for the 2021 Mercedes-Benz E450, the most recent from February 9, 2024 (wiring). Recall repairs are free at any authorized dealer — check whether yours has been done with the VIN recall check.
What are the best and worst years of the Mercedes-Benz E450?
The best years by complaints, compared at the same age, are 2025 and 2024. Years to avoid or approach with caution: 2023. See the full Mercedes-Benz E450 years comparison.
At what mileage do 2021 Mercedes-Benz E450 problems happen?
The median mileage reported in complaints is about 1,000 miles; 100% of problems with a recorded mileage started before 50,000 miles.
Source: U.S. National Highway Traffic Safety Administration (NHTSA) — owner complaints through October 20, 2026, recalls and defect investigations; fuel economy from the EPA. Complaints are unverified reports and are not proof of a defect. How we rate model years.