Most common 2022 Mercedes-Benz E450 problems
Share of the 11 complaints; one complaint can involve more than one system. "~" is the median mileage when the problem started.
Mercedes-Benz E450 complaints by model year
Best E450 years: 2025, 2024. Years to avoid: 2023. Compare all years →
2022 Mercedes-Benz E450 recalls (5)
Electrical system › Wiring
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 CLS450, E450, E450 All-Terrain, AMG E53, AMG GT43, AMG GT53, and 2021 AMG CLS53 vehicles. The 48-volt ground cable connection located in the engine compartment may not be tightened properly and may result in the ground cable overheating.
Remedy: Dealers will inspect the 48-volt ground cable connection and repair it as necessary, free of charge. Owner notification letters were mailed March 22, 2024. Owners may contact MBUSA customer service at 1-800-367-6372.
Fuel system, gasoline › Delivery › Fuel pump
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2024 GLE, GLS, C-Class, E-Class, S-Class, SL, GLC, CLS, AMG GT, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, causing a loss of drive power.
Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 28, 2024. Owner notification letters will be mailed in phases, on February 23, 2024, April 19, 2024, June 28, 2024,…
Fuel system, gasoline › Delivery › Fuel pump
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2023 C-Class, E-Class, S-Class, CLS, SL, GT, GLC, GLE, GLS, and G-Class vehicles. Please refer to MBUSA's recall report for specific vehicle details. The fuel pump may shutdown, which can result in a loss of drive power.
Remedy: Dealers will replace the fuel pump, free of charge. Owner notification letters were mailed on June 14, 2024. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2023070012.
Electrical system › 12V/24V/48V battery
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2019-2022 CLS450 Coupe and AMG E53, 2019-2021 AMG CLS53 Coupe, and 2021-2022 E450 vehicles. The 12-Volt battery in the trunk may not be properly secured, which, in the event of a crash, can cause electrical connection failure, disabling various safety features including,…
Remedy: Dealers will secure the 12V battery, free of charge. Owner notification letters were mailed January 20, 2023. Owners may contact MBUSA customer service at 1-800-367-6372. MBUSA's number for this recall is 2022100009.
Steering › Steering wheel/handle bar
Mercedes-Benz USA, LLC (MBUSA) is recalling certain 2021-2022 C-Class, E-Class, S-Class, SL, EClass Coupe/Convertible, CLS, AMG GT 4-doors Coupe, and EQS vehicles with a heated leather steering wheel.
Remedy: Dealers will update the hand detection control unit software for the DISTRONIC system, free of charge. Owner notification letters were mailed May 6, 2022. Owners may contact MBUSA customer service at 1-800-367-6372.
What 2022 Mercedes-Benz E450 owners say
Electrical system
The contact owns a 2020 Mercedes-Benz E450. The contact stated that on three occasions the driver's side front seat independently adjusted when the vehicle was started. On another occasion, the vehicle started by independently. Additionally, the head-up projected display moved up the windshield instead of remaining in place. The contact stated that the battery warning light was illuminated. The contact stated that on several occasions the vehicle stalled. The vehicle was able to be restarted intermittently. The vehicle was taken to a dealer where it was diagnosed and there was unknown software that needed to be updated. The vehicle was not repaired. The manufacturer was notified of the failure. The failure mileage was approximately 400.
Twice within a year a "48 voltage battery malfunction" warning appeared on my dashboard. Then a red warning light appears and I had about 30 seconds to find a safe place to pull over as loss of power causes deceleration of the vehicle . The cause, according to the diagnostic test performed by 2 different Mercedes dealerships, is that a software update is needed. A know of no situation where the machine crashes first then you're told to update its software. I am concerned that this will unexpectedly happen again and possibly on a road where pulling over to a shoulder may not be possible in the little time given before power failure.
Fuel & propulsion system
The contact owns a 2022 Mercedes Benz E450. The contact received notification of NHTSA Campaign Number: 23V445000 (Fuel System, Gasoline) however, the part to do the recall repair was not yet available. The local dealer was made aware of the issue and confirmed that parts were not yet available. The contact stated that the manufacturer had exceeded a reasonable amount of time for the recall repair. The manufacturer was made aware of the issue. The contact had not experienced a failure. VIN tool showed no open recall.
The contact owns a 2022 Mercedes-Benz E450. The contact received notification of NHTSA Campaign Number: 23V445000 (Fuel System, Gasoline) however, the part to do the recall repair was unavailable. The contact stated that the manufacturer had exceeded a reasonable amount of time for the recall repair. The manufacturer was not made aware of the issue. The contact had not experienced a failure. VIN tool confirms parts not available.
2022 Mercedes-Benz E450 engines & fuel economy
| Engine | Transmission | Drive | MPG city / hwy / combined |
|---|---|---|---|
| 3.0L 6-cyl turbo hybrid | 9-speed automatic | RWD | 22 / 29 / 25 |
EPA ratings. Class: Subcompact car.
Frequently asked questions
Is the 2022 Mercedes-Benz E450 a good car?
Based on 11 owner complaints filed with NHTSA, the 2022 E450 rates average: 1.4× as many complaints as a typical year of the E450 at the same age. Complaint counts don't account for sales volume or individual maintenance, so have any used car inspected before buying.
What is the most common problem with the 2022 Mercedes-Benz E450?
The electrical system — 4 complaints, 36% of all complaints for this model year. Next are the fuel & propulsion system (3) and wheels & tires (2).
How many recalls does the 2022 Mercedes-Benz E450 have?
There are 5 recalls for the 2022 Mercedes-Benz E450, the most recent from February 9, 2024 (wiring). Recall repairs are free at any authorized dealer — check whether yours has been done with the VIN recall check.
What are the best and worst years of the Mercedes-Benz E450?
The best years by complaints, compared at the same age, are 2025 and 2024. Years to avoid or approach with caution: 2023. See the full Mercedes-Benz E450 years comparison.
At what mileage do 2022 Mercedes-Benz E450 problems happen?
The median mileage reported in complaints is about 0 miles; 100% of problems with a recorded mileage started before 50,000 miles.
Source: U.S. National Highway Traffic Safety Administration (NHTSA) — owner complaints through October 20, 2026, recalls and defect investigations; fuel economy from the EPA. Complaints are unverified reports and are not proof of a defect. How we rate model years.