Which parts fail
Components named in complaints (engine, cooling system, oil leaks, timing chain, exhaust).
Mileage when the problem started
Owner reports
Selected complaints filed with NHTSA by 2007 Mercedes-Benz E350 owners, lightly cleaned up (personal details are redacted by NHTSA).
The contact owns a 2007 Mercedes-Benz E350. The contact stated that while the vehicle was parked with the engine running, the contact heard a loud rattling sound coming from the engine compartment. The contact called an independent mechanic and was informed that the camshaft balancer was damaged and needed to be replaced. The vehicle was not repaired. The manufacturer was not made aware of the failure. The failure mileage was approximately 257,000.
Vehicle began shaking on the highway. It was coming from under the front hood and was shaking the steering wheel. The check engine light came on. I pulled over and had it towed to the Mercedes repair shop. They said it was related to a bad balance shaft and that it was a systemic problem with the engine in certain Mercedes e350s. I was told I needed to replace the camshaft and it would cost $6,000!!! After some research, it looks like Mercedes agreed, back in 2015, to cover only certain of these Mercedes, but there was no recall. I could have been killed if I was rear ended.
Tl* the contact owns a 2007 Mercedes-Benz E350. While driving various speeds, the battery warning indicator illuminated. In addition, the power steering became difficult to maneuver and the vehicle stalled. Also, the check engine warning indicator remained illuminated. The contact was unable to restart the vehicle. The vehicle was towed to Mercedes-Benz of west chester (located at 1260 wilmington pike, west chester, pa 19382, [phone]) where it was diagnosed that the fuel pump needed to be replaced. The fuel pump was replaced; however, the failure recurred twice. Additionally, the fuel pump filer, water pump, tensioner pulley, and serpentine belt (which was replaced nine times) were replaced, but the failure recurred. The contact was also informed that there was an electronic failure for which the mechanic was unable to repair. …
30 aug.16 took my 07 E350 with 29427 miles to the dealership because the check engine light came on and the car was hard starting. After arriving I informed the service writer the car had shut down while driving. We were proceeding through a busy major intersection when the car shut down. Luckily it started so we could safely exit the busy major intersection. After a diagnostic test was ran, I was informed the crankshaft hall sensor was defective. Additionally, the engine control unit, engine wiring harness, crank sensor and various other components are oil soaked. I notified Mercedes Benz to be told the car was out of warranty. Mercedes Benz should be held accountable for the unsafe defective materials they use. The above issues are a danger to the occupants and general public as well. The defective oil soaked wiring harness is can cause a fire. …
The engine stalled while in motion and driving over 45 MPH. This is the 2nd time this has occurred. Both times I was travelling over 45 MPH on a large and busy city street and had difficulty steering my car to safety. There are no codes to explain what might be the cause. Replaced the transmission control unit the first time. After removing the key, putting the car in park and waiting for 5-10 minutes, in both occurrences I was able to restart the vehicle and drive to the dealership, which was less than 5 miles from my location.
My vehicle shut off while I was driving on a main street. Two minutes later I could start it. Then next day I could so I took it to a trusted mechanic and was informed about recall. It hasn't started since. The mechanic isn't certain about exactly the problem but said there was some misfires on sensors. Unknown exactly what's wrong. I did get a letter in the mail about a recall offered to me if similar conditions happen.
While driving on freeway, engine suddenly revved high and almost red-lined on RPM gauge. Exited freeway and RPM (while lowered) was still high. A 3rd party mechanic diagnosed transmission valve body failure and advised on replacement. This must be a a known issue because mechanic asked that in order to replace the part a valid personal id must be recorded as part of the parts replacement per Mercedes.
Upon filling up gas tank you can smell gas around the rear of the vehicle. This happens for the first day or two after filling up and then becomes less and less over time until you fill up again. There is a much stronger smell when inside an enclosed garage and I am worried about the fumes being ignited by a water heater pilot flame.
The front inner tires get cupping over the time, I have to replace them every 10,000 miles. All the suspension parts are new put still the problem going on. It is a manufacturing problem with the heavy engine get the load on the power train and with the time it losing and make the tires cupping from the inner side.
My car was running suddenly stop and does not start, I take it to Mercedes dealer and they charge me $195.00 plus tax to scanned it they found the ECM engine control module need to be replace. Cost is $2,300 plus tax. Please contact me for at your convenience so I can take further steps towards Mercedes Benz.
Engine complaints in other E350 years
Frequently asked questions
How common are engine problems on the 2007 Mercedes-Benz E350?
NHTSA has 33 complaints about the engine & cooling of the 2007 Mercedes-Benz E350, 9% of the model year's 350 complaints. The component named most often is engine (1 mentions).
Is there a recall for 2007 Mercedes-Benz E350 engine problems?
No. NHTSA lists no engine & cooling recall for the 2007 Mercedes-Benz E350, though it has 5 recalls for other components. If the problem is widespread, a repair may still be covered by an extended warranty or a manufacturer service bulletin — ask a dealer.
At what mileage do 2007 Mercedes-Benz E350 engine problems start?
Half of the complaints with a recorded mileage happened before about 93,000 miles, and 7% before 25,000 miles.
Source: U.S. National Highway Traffic Safety Administration (NHTSA) — owner complaints through October 20, 2026, recalls and defect investigations; fuel economy from the EPA. Complaints are unverified reports and are not proof of a defect. How we rate model years.