Most common 2021 Ford E-350 problems
Share of the 22 complaints; one complaint can involve more than one system. "~" is the median mileage when the problem started.
Ford E-350 complaints by model year
Best E-350 years: 2018, 2016, 2015. Years to avoid: 1997, 1995, 1999. Compare all years →
2021 Ford E-350 recalls (6)
Engine
Ford Motor Company (Ford) is recalling certain 2021 E-350 and E-450 vehicles that received an incomplete software update under recall 20V795. The engine cover may become excessively hot.
Remedy: Dealers will update the powertrain calibration for heat management under elevated idle conditions, free of charge. Owner notification letters were mailed January 7, 2026.
Service brakes, hydraulic › Foundation components › Hoses, lines/piping, and fittings
Ford Motor Company (Ford) is recalling certain 2021-2022 E-350 and E-450 vehicles equipped with dual rear wheels. An inadequate connection between the power steering pressure line and the brake hydroboost unit may result in a sudden loss of power steering fluid.
Remedy: Dealers will replace the power steering pressure line and the hydroboost jumper line, free of charge. Vehicles in this recall were previously recalled under 22V-089 and owners will need to have the new remedy completed…
Service brakes, hydraulic › Foundation components › Hoses, lines/piping, and fittings
Ford Motor Company (Ford) is recalling certain 2021-2022 E-350 and E-450 vehicles equipped with dual rear wheels. An inadequate connection between the power steering pressure line and the brake Hydroboost unit may result in a sudden loss of power steering fluid.
Remedy: Dealers will inspect the connection between the power steering lines and the Hydroboost unit, and replace the power steering lines, as necessary, free of charge. Owner notification letters were mailed on March 18, 2022.
Engine
Ford Motor Company (Ford) is recalling certain 2021 E-350 and E-450 vehicles. The underside of the engine cover may have mispositioned insulation, allowing the cover to get excessively hot.
Remedy: Ford will notify owners, and dealers will inspect the engine cover for gaps between the rubber seal and the insulation. If gaps are present, the dealer will install engine cover insulation patches in the right hand and…
Electronic stability control (ESC)
Ford Motor Company (Ford) is recalling certain 2021 E-350 and E-450 vehicles. A wire harness in the rear of the vehicle may contact the vehicle frame, resulting in damage to the circuits that support the fuel pump and the anti-lock braking system (ABS).
Remedy: Ford will notify owners, and dealers will inspect the wire harness for damage. If no damage is found, dealers will apply anti-abrasion tape over the area and ensure clearance to surrounding components.
Power train › Driveline › Differential unit
Ford Motor Company (Ford) is recalling certain 2020 F-550 and 2021 E-350 and E-450 vehicles. The rear axle differential fluid may be below the minimum level, possibly resulting in a failure of the rear axle assembly and driveshaft separation.
Remedy: Ford will notify owners, and dealers will inspect the rear axle differential fluid level and adjust it, or replace the rear axle as necessary, free of charge. The recall began March 19, 2020.
NHTSA defect investigations
Federal safety investigators have looked into a possible defect involving the 2021 Ford E-350:
Loss of Power Brake/Steering Assist Post Recall 22V089 Inspection.
The Office of Defects Investigation (ODI) opened Recall Query (RQ) 24003 on February 27, 2024, to evaluate the scope and remedy effectiveness of NHTSA recall 24V097. On February 16, 2022, Ford Motor Company (Ford) issued a safety recall, NHTSA recall 22V089, for certain 2021-2022 Ford E-350 and E-450 vehicles equipped with dual rear wheels.
What 2021 Ford E-350 owners say
Engine & cooling
The contact owns a 2021 FORD E-350. The contact received notification of NHTSA Campaign Number: 20V795000 (ENGINE) however, the dealer informed the contact that only one part of the remedy, mentioned on the manufacturer's website, was available and not the other. The contact received the reprogramming (UPDATE THE POWERTRAIN CALIBRATION) mentioned on the Ford website but not the other portion of the repair mentioned on the website (INSTALL ENGINE COVER INSULATION PATCHES IN THE RIGHT HAND AND LEFT HAND INNER LOWER CORNERS OF THE ENGINE COVE). The contact stated that the failure reoccurred and that when they looked up the recall on the NHTSA website stated that there was no recall repair available at all. The contact stated that the manufacturer exceeded a reasonable amount of time for the recall repair. The manufacturer was made aware of the issue. …
Engine failure at 78,172, excess wear to the camshaft lobes and valve tappet surface. We have had 22 failures. There was a recall -24B27 for 2021 and 2022 models year for idle oil pressure. Most vans had 70 to 80k on them by the time we received a letter. Some engine have been changed twice. Ford has a serious problem and is not acknowledging it. Please help! Montachusett Regional Transit Authority , Fitchburg MA 01420
Steering
The contact owns a 2021 Ford E-350. The stated while driving into the driveway, the vehicle made an abnormal popping sound. The vehicle lost power steering functionality, and the brake pedal became spongy. Additionally, the contact stated that there was a trail of fluid in the driveway. The contact stated that upon opening the hood, he noticed that the brake line had fractured, and brake fluid was leaking inside the engine compartment. There was no further information provided. The manufacturer was notified of the failure and referred the contact to a dealer; however, the dealer could not accommodate the vehicle. The dealer was contacted and diagnosed the vehicle at the contact's residence. The dealer determined that unknown hoses needed to be replaced and the failure was related to NHTSA Campaign Number: 22V089000 (Steering, Service Brakes, Hydraulic). …
The contact owns a 2021 Ford E-350. The contact's wife was driving into a parking lot at approximately 5 MPH when the power steering and the brakes failed. The contact's wife was able to safely stop the vehicle. The contact stated that his wife had not observed any warning lights being illuminated. The contact's wife examined the vehicle and noticed that there was red fluid puddling on the ground and a hissing sound coming from the driver's side under the engine. The vehicle had not been towed to a dealer and had not been diagnosed or repaired. The contact researched online and related the failure to NHTSA Campaign Number: 22V089000 (Steering, Service Brakes, Hydraulic). The manufacturer had not been informed of the failure. The failure mileage was approximately 22,000. …
Brakes
The contact owns a 2021 Ford E-350. The stated while driving into the driveway, the vehicle made an abnormal popping sound. The vehicle lost power steering functionality, and the brake pedal became spongy. Additionally, the contact stated that there was a trail of fluid in the driveway. The contact stated that upon opening the hood, he noticed that the brake line had fractured, and brake fluid was leaking inside the engine compartment. There was no further information provided. The manufacturer was notified of the failure and referred the contact to a dealer; however, the dealer could not accommodate the vehicle. The dealer was contacted and diagnosed the vehicle at the contact's residence. The dealer determined that unknown hoses needed to be replaced and the failure was related to NHTSA Campaign Number: 22V089000 (Steering, Service Brakes, Hydraulic). …
The contact owns a 2021 Ford E-350. The contact's wife was driving into a parking lot at approximately 5 MPH when the power steering and the brakes failed. The contact's wife was able to safely stop the vehicle. The contact stated that his wife had not observed any warning lights being illuminated. The contact's wife examined the vehicle and noticed that there was red fluid puddling on the ground and a hissing sound coming from the driver's side under the engine. The vehicle had not been towed to a dealer and had not been diagnosed or repaired. The contact researched online and related the failure to NHTSA Campaign Number: 22V089000 (Steering, Service Brakes, Hydraulic). The manufacturer had not been informed of the failure. The failure mileage was approximately 22,000. …
Frequently asked questions
Is the 2021 Ford E-350 a good car?
Based on 22 owner complaints filed with NHTSA, the 2021 E-350 rates average: about as many complaints as a typical year of the E-350 at the same age. Complaint counts don't account for sales volume or individual maintenance, so have any used car inspected before buying.
What is the most common problem with the 2021 Ford E-350?
The engine & cooling — 11 complaints, 50% of all complaints for this model year. Next are the steering (7) and brakes (7).
How many recalls does the 2021 Ford E-350 have?
There are 6 recalls for the 2021 Ford E-350, the most recent from November 17, 2025 (engine). Recall repairs are free at any authorized dealer — check whether yours has been done with the VIN recall check.
What are the best and worst years of the Ford E-350?
The best years by complaints, compared at the same age, are 2018, 2016 and 2015. Years to avoid or approach with caution: 1997, 1995 and 1999. See the full Ford E-350 years comparison.
At what mileage do 2021 Ford E-350 problems happen?
The median mileage reported in complaints is about 14,000 miles; 100% of problems with a recorded mileage started before 50,000 miles.
Source: U.S. National Highway Traffic Safety Administration (NHTSA) — owner complaints through October 20, 2026, recalls and defect investigations; fuel economy from the EPA. Complaints are unverified reports and are not proof of a defect. How we rate model years.